SAMe

200mg

S-Adenosyl-L-Methionine (SAMe) plays a pivotal role in various physiological functions and serves as the central link connecting three crucial metabolic pathways. Recognized as a unique methyl donor in over 100 biological reactions, SAMe is notably involved in DNA methylation. Additionally, it connects methylation to polyamine synthesis, essential for cell survival and development, and transsulfuration, responsible for producing cysteine—a key factor in glutathione synthesis. This distinctive position within these interconnected pathways elucidates SAMe's function as a regulator of redox status, cellular metabolism, proliferation, and apoptosis.

Clinically, SAMe has demonstrated effectiveness in supporting various conditions, particularly osteoarthritis, fibromyalgia, neurodegenerative diseases, depression, and liver disease. For individuals with major depressive disorder, SAMe has proven effective not only compared to standard antidepressants but also for those who do not respond to selective serotonin reuptake inhibitors (SSRIs). SAMe has shown the added benefit of reducing the incidence of Intimacy dysfunction often associated with SSRI/SNRI therapy. Moreover, SAMe has exhibited efficacy for osteoarthritis comparable to nonsteroidal anti-inflammatory drugs (NSAIDs), including celecoxib. Notably, its effectiveness is likely attributed to increases in cartilage formation, glutathione production, DNA methylation, and gene expression, setting it apart from pharmaceutical analgesics. Research also suggests potential benefits for neurodegenerative diseases and possibly improving endothelial function.

Benefits

• Key factor in several biological pathways, including methylation reactions, glutathione formation and glutathione S-transferase activity

• Enteric coating protects SAMe degradation from gastric acid, allowing for significantly improved intestinal absorption

• 200 mg SAMe per tablet for flexible-dose titration

• SAMe is produced through a natural fermentation process that yields higher active ingredients over synthetic variations

Medicinal Ingredients

Each Tablet Contains:

S-Adenosyl-L-Methionine (SAMe)
200 mg

 

Non-Medicinal Ingredients

Microcrystalline cellulose, coating (talc, glycerin, arginine, vegetable grade magnesium stearate (lubricant), silica, sodium alginate), stearic acid, vegetable grade magnesium stearate (lubricant), magnesium hydroxide, silica, calcium oxide.

Dosage

Recommended Adult Dose: SAMe should always be taken on an empty stomach and for a minimum of 2 weeks, at which time effects should be observed.

For mood balance: 1-4 tablets 2 times per day or as directed by a health Wellness-Care practitioner. Consult a health Wellness-Care practitioner for use beyond 6 weeks.

For osteoarthritic pain: 2 tablets 3 times per day or as directed by a health Wellness-Care practitioner. Not to exceed 6 tablets per day. Consult a health Wellness-Care practitioner for use bevond 12 weeks.

Warnings

Consult a health Wellness-Care practitioner prior to taking SAMe if taking anti-depressants, hepatotoxic drugs or monoamine oxidase (MA) inhibitors. Not recommended for use in children. Do not use if you are pregnant or breastfeeding or if you have bipolar disorder (manic-depressive illness). Do not take at night as SAMe may cause anxiety, restlessness, and insomnia. Possible side effects are: mild gastrointestinal upsets (such as stomach pain, nausea, diarrhea, and flatulence), anxiety, hyperactive muscle movement, insomnia, and hypomania. When these side effects occur, they often diminish with time or resolve with lower doses or cessation of use. Keep out of reach of children.

Allergens

Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs.

Contraindications

If you are taking antidepressants, hepatotoxic drugs or monoamine oxidase (MAO) inhibitors, consult a health Wellness-Care practitioner prior to taking SAMe in place of or in addition to those Health Products. Not recommended for use in children. Do not use if you are pregnant or breastfeeding. Do not take at night as SAMe may cause anxiety, restlessness and insomnia. People with bipolar disorder (manic-depressive illness) should not use SAMe unless under medical supervision. Possible side effects are: mild gastrointestinal upsets (such as stomach pain, nausea, diarrhea, flatulence), anxiety, hyperactive muscle movement, insomnia and hypomania. When these side effects occur they often diminish with time or resolve with lower doses or cessation of use. There are no documented cases of allergies to SAMe. Keep out of reach of children.

Drug Interactions

Deficiency of vitamins B6, B12, and other methyl donors may exacerbate SAMe deficiency. Theoretically, may have additive serotonergic effects when used with antidepressants, but when used simultaneously, no increase in adverse effects were noted compared to placebo.

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