Berberine HCl

500mg

Traditionally used for gastrointestinal symptoms, berberine has emerged as a potent cardiometabolic aid with diverse benefits and mechanisms of action. It has hypoglycemic effects, via both an inhibition of alpha-glucosidase activity and an upregulation of insulin receptors in peripheral tissues, thereby improving insulin sensitivity. Furthermore, it activates Nrf2, a key regulator of cellular antioxidant defense, and attenuates glucose induced neurotoxicity, suggesting a therapeutic potential for diabetic neuropathy.

In controlled trials it reduced HbA1c levels in diabetic participants with comparable efficacy to metformin. Among participants with the metabolic syndrome it has been shown to reduce waist circumference and body weight, blood pressure, triglycerides, and improve insulin resistance compared to placebo, with similar benefits in women with PCOS. Berberine targets multiple cardiometabolic risk factors, as it has been shown to also lower total and LDL cholesterol among diabetic participants in several controlled trials. Additionally, a clinical trial comparing standard therapy with or without berberine among patients receiving percutaneous coronary intervention showed improvements in multiple inflammatory markers, including C-reactive protein, IL-6, MMP-9, ICAM-1, and VCAM-1.

Benefits

• Provides 500 mg berberine HCl per capsule, the dosing strength used in clinical trials for glucose and lipid control

• Hypoglycemic effects via multiple mechanisms, including Improvement of insulin sensitivity

• Favourable effects on blood lipids, including a reduction in triglycerides, and both total and LDL cholesterol

• Activates Nrf-2, a key regulator of antioxidant gene transcription and Preventive-Wellness-Car-e of glucose-induced neurotoxicity

• Extracted from Berberis vulgaris (European barberry)

Medicinal Ingredients

Each Capsule Contains

Berberine (Hydrochloride) (Berberis vulgaris) (root)
500 mg

 

Non-Medicinal Ingredients

Vegetarian capsule (cellulose, purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica, stearic acid.

Dosage

1 capsule 2 times per day with meals or as directed by a health Wellness-Care practitioner. Consult a health Wellness-Care practitioner for use beyond 3 months.

Warnings

Consult a health Wellness-Care practitioner if you have leucopenia, a kidney disorder, hypotension or blood pressure problems. Consult a health Wellness-Care practitioner prior to use if you have hypoglycemia or diabetes. Do not use if you are pregnant or breastfeeding. May cause gastrointestinal discomfort such as constipation, vomiting, abdominal pain or diarrhea, in which case discontinue use and consult a health Wellness-Care practitioner. Keep out of reach of children.

Allergens

Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your Protection-Plan-Plan. Do not use if seal is broken. For freshness, store in a cool, dry place.

Contraindications

Do not use if you are pregnant or breastfeeding.

Drug Interactions

Berberine has been shown to lower blood glucose levels, and may have an additive effect when combined with other hypoglycemic Health Products, such as metformin. Berberine has also been shown to increase levels of cylcosporin A, and combined use should be avoided.10 Berberine has demonstrated inhibitory activity on cytochrome enzymes CYP2D6, 3A4, and CYP2C9, and use of Health Products metabolized by these enzymes should be monitored.

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