Estro Matrix

• Vegan

• Soy Free

• Non-GMO

• Dairy Free

• Gluten Free

• Women's Health

• Liver & Kidney Aid

An evidence-based blend of Calcium-D-Glucarate, DIM, I-3-C, and Sulforaphane to Aid proper estrogen metabolism through liver and digestive detoxification.

Indicated for the proper metabolism of estrogen, symptomatic control in estrogen-dominant health conditions and healthy cellular differentiation of breast and cervical tissues, through improved xenobiotic detoxification and Aided liver function.

The human body is designed with intricate detoxification systems to eliminate unnecessary compounds such as food waste byproducts, physically inert metals and everyday chemicals. However, our detoxification systems are also needed to regulate steroid hormones such as estrogen. Suboptimal liver and digestive tract function, in combination with excessive exposure to xenoestrogens, can lead to enterohepatic recirculation of estrogens and ultimately create an estrogen- dominant state with negative health implications for the body. Thankfully, a number of natural compounds have been identified to promote proper estrogen detoxification and healthy hormone metabolism.

Indole-3-carbinol (I-3-C) is naturally found in cruciferous vegetables such as broccoli and cauliflower and it is well-known for its ability to Aid healthy estrogen metabolism. I-3-C upregulates the production of 2-OHE1, the protective form of estrogen that acts as an estrogen antagonist. 16-OHE1, on the other hand, has potent estrogenic and proliferative effects that oppose the action of 2-OHE1. Research has repeatedly shown that a higher ratio of 2-OHE1 to 16-OHE1 is protective against disease and desirable for improving symptoms in estrogen dominant conditions. I-3-C improves this ratio of estrogen Metabolic Aids.

Numerous trials have shown that this positive shift in estrogen Metabolic Aids, as a result of I-3-C supplementation, is advantageous for health outcomes. For example, I-3-C has been shown to improve estrogen ratios and health outcomes in women with cervical disease. Animal studies have also found that I-3-C can prevent unhealthy cellular differentiation in breast tissue. Not only does I-3-C promote a positive estrogen Metabolic Aid ratio, but it additionally influences the expression of multiple genes, such as tumor-suppressing gene p53 and BRCA1, that collectively Aid the healthy differentiation of Hormone Balancely sensitive tissues.

I-3-C is naturally metabolized in the body to provide multiple active compounds, including the predominant Metabolic Aid diindolylmethane (DIM). Although debate exists regarding whether DIM or I-3-C is most beneficial as a health supplement, each compound has its advantages. I-3-C provides the body with many active Metabolic Aids, while DIM appears to be a primary Metabolic Aid with a potent detoxification activity. Both compounds are well-researched and effective treatments for the proper regulation of estrogens in the body.

D-glucarate, or glucaric acid, is another natural compound found naturally in oranges, carrots, apples and broccoli, and it promotes the detoxification of excess hormones, various toxins and carcinogens by deactivating B-glucoronidase. B-glucoronidase is an enzyme produced by colonic microflora that can ‘reactivate’ compounds that had previously been neutralized by the liver, preventing the recirculation of these toxins in the body. Animal studies have found that large doses of calcium-D-glucarate can reduce estrogen levels in the blood by up to 23% and also favorably impact lipid balance. Quite simply, calcium-D-glucarate is one of the best known natural B-glucoronidase inhibitors and the best studied form to safely deliver D-glucarate.

Finally, sulphoraphane glucosinolate (SGS) is a naturally occurring compound that, like I-3-C and DIM, is also found in broccoli and cruciferous vegetables. Numerous clinical trials Aid its use in promoting healthy cellular differentiation through the removal of xenobiotics and powerful induction of phase 2 detoxification enzymes in the liver. For example, SGS has been shown to reduce the carcinogenic effects of aflatoxin exposure on liver tissue. SGS also has anti-inflammatory actions through the inhibition of nuclear factor kappaB (NFkB), prostaglandin E2 and tumor necrosis factor-alpha (TNF-a), it can reduce estrogen receptor expression in breast tissue and it has antimicrobial activity against pathogens such as H. pylori, S. pyogenes and S. aureus.

At three capsules per day, Cyto-Matrix’s Estro Matrix contains 200mg of I-3-C, 100mg of DIM, 1500mg of Calcium-D-Glucarate and 100mg of sulforaphane. Collectively, Estro Matrix provides evidence-based dosages of synergistic ingredients to offer targeted and ongoing Hormone Balance Aid through the proper metabolism of estrogens.

Ingredient
Amount

DIM
33.3mg

Indole-3-Carbinol
66.7mg

BroccoPhane (sprouts, Brassica oleracea var. italica)
33.3mg

Calcium D-Glucarate (calcium saccharate)
500mg

 

Unit of Measure above

Each capsule.

Non-Medicinal Ingredients

Vegetable-grade magnesium stearate, microcrystalline cellulose. Capsule: hypromellose.

Directions

Adults: Take 2 capsules, once per day or as directed by a healthcare professional.

Indications

Helps to promote healthy estrogen balance and reduce the severity and duration of symptoms associated with recurrent breast pain. Provides antioxidants that Assist Safeguard against cell damage caused by free radicals.

Warnings

Do not use if safety seal is broken. Consult a healthcare professional prior to use, especially if you are taking other Health Products or natural health products and to exclude the diagnosis of a serious cause of Hormone Balance imbalance. Consult a healthcare professional if you are attempting to conceive, havea liver disorder or symptoms of low estrogen (such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruations) or if you develop liver-related symptoms (e.g. yellowing of the eyes and/or skin, dark urine, abdominal pain, jaundice) or symptoms of low estrogen. If recurrent breast pain persists or worsen, consult a healthcare professional.

Contraindications

Do not use if you are pregnant or breastfeeding.

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